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G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma

Wenjing Wang, Shigang Ding, Hejun Zhang, Jun Li, Jun Zhan, Hongquan Zhang

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 482-491 doi: 10.1007/s11684-018-0633-0

Abstract: This study aimed to clarify whether the expression level of LGR6 is correlated with colon adenocarcinomaImmunohistochemistry was used to detect LGR6 expression in colon adenoma tissues ( = 21), colon adenocarcinomaThe expression levels of LGR6 in colon adenoma and adenocarcinoma were significantly higher than thoseLow LGR6 expression predicted a short overall survival in patients with colon adenocarcinoma (log-rankadenocarcinoma.

Keywords： LGR6     colon adenocarcinoma     immunohistochemistry     prognosis    

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Bioinformatic exploration of MTA1-regulated gene networks in colon cancer

Chunxiao Li,Haijuan Wang,Feng Lin,Hui Li,Tao Wen,Haili Qian,Qimin Zhan

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 178-182 doi: 10.1007/s11684-016-0442-2

Abstract: Results showed that in the development of colon cancer, MTA1 is linked to certain signal pathways, such

Keywords： metastasis-associated gene 1     colon cancer     bioinformatics    

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Pyogenic liver abscess as initial presentation in locally advanced right colon cancer invading the liver

Kai Qu, Chang Liu, Aasef M A Mansoor, Bo Wang, Jincai Chen, Liang Yu, Yi Lv

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 434-437 doi: 10.1007/s11684-011-0157-3

Abstract: In the present paper, we report on a patient with advanced right colon cancer, including liver, gallbladderHowever, the clinical manifestation of locally advanced colon cancer was extremely complicated.

Keywords： liver abscess     locally advanced colon cancer     multiorganic invasion    

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Invasive mucinous adenocarcinoma with lepidic-predominant pattern coexisted with tuberculosis: a case

Xinxin Xu, Yinshi Guo, Qiuying Li, Ling Yang, Jianqiang Kang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 330-333 doi: 10.1007/s11684-017-0545-4

Abstract:

We observed a rare case of invasive mucinous adenocarcinoma (IMA) with a lepidic-predominant pattern

Keywords： invasive mucinous adenocarcinoma     lepidic-predominant     tuberculosis    

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Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell

SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 359-363 doi: 10.1007/s11684-007-0069-4

Abstract: Taken together, the inhibition of pirh2 expression in the lung adenocarcinoma cell line A549 resulted

Keywords： control     interruption     cytoplasm     number     growth    

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Synchronous rectal adenocarcinoma and anal canal adenocarcinoma

GU Jin, YAO Yunfeng, LI Jiyou, LU Aiping, WANG Hongyi

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 333-337 doi: 10.1007/s11684-007-0064-9

Abstract: Here, we report on the case of a 63-year-old man who presented with an upper-third rectal adenocarcinomaFive months after resection, he developed an adenocarcinoma in the anal canal.

Keywords： CK7+/CK20+     resection     different     therapeutic strategy     upper-third    

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Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis

Rui ZHU MD, Heng FAN MD, Lin SHEN MD, Jianguo LIU BD, Jia ZHAO MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 475-479 doi: 10.1007/s11684-009-0086-6

Abstract: The expression of signal transducer and activator of transcription 6 (STAT6) and nuclear factor-κB (NF-κB) in the colonic mucosa of patients with ulcerative colitis (UC) was examined. Real-time polymerase chain reaction and immunohistochemistry were used to detect the expression of STAT6 and NF-κB p65 at both mRNA and protein levels in the colonic mucosa of patients with UC and healthy volunteers. The results showed that the expression levels of STAT6 and NFκB p65 in the colonic mucosa of patients with UC were significantly higher than in normal controls at both mRNA and protein levels. These data suggest that STAT6 and NFκB p65 perhaps play an important role in the pathogenesis of UC and underscore the potential value of anti-UC strategies in the clinical management of this disease.

Keywords： ulcerative colitis     signal transducer and activator of transcription 6 (STAT6)     nuclear factor-κ     B p65 (NF-κ     B p65)    

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Diversity of the N-Glycome from Microdissected Regions of Colorectal Cancer, Stroma, and Normal Colon Article

Di Wang, Katarina Madunić , Tao Zhang, Guinevere S.M. Lageveen-Kammeijer, Manfred Wuhrer

Engineering 2023, Volume 26, Issue 7,   Pages 32-43 doi: 10.1016/j.eng.2022.08.016

Abstract:

Aberrant glycosylation is considered to be a hallmark of colorectal cancer (CRC), as demonstrated by various studies. While the N-glycosylation of cell lines and serum has been widely examined, the analysis of cancer-associated N-glycans from tissues has been hampered by the heterogeneity of tumors and the complexity of N-glycan structures. To overcome these obstacles, we present a study using laser capture microdissection that makes it possible to largely deconvolute distinct N-glycomic signatures originating from different regions of heterogeneous tissues including cancerous, stromal, and healthy mucosa cells. N-glycan alditols were analyzed by means of porous graphitized carbon liquid chromatography-electrospray ionization tandem mass spectrometry, enabling the differentiation and structural characterization of isomeric species. In total, 116 N-glycans were identified that showed profound differences in expression among cancer, stroma, and normal mucosa. In comparison with healthy mucosa, the cancer cells showed an increase in α2-6 sialylation and monoantennary N-glycans, as well as a decrease in bisected N-glycans. Moreover, specific sialylated and (sialyl-)LewisA/X antigen-carrying N-glycans were exclusively expressed in cancers. In comparison with cancer, the stroma showed lower levels of oligomannosidic and monoantennary N-glycans, LewisA/X epitopes, and sulfation, as well as increased expression of (core-)fucosylation and α2-3 sialylation. Our study reveals the distinct N-glycomic profiles of different cell types in CRC tumor and control tissues, proving the necessity of their separate analysis for the discovery of cancer-associated glycans.

 

Keywords： Colorectal cancer     Tumor     Porous graphitized carbon liquid chromatography mass spectrometry     N-glycomics     Antibody response    

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Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma

Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 275-291 doi: 10.1007/s11684-020-0779-4

Abstract: By integrating a large-scale genotype data of 15 581 lung adenocarcinoma (AD) cases, 8350 squamous cell

Keywords： lung cancer     genome-wide association study     function annotation     immune     homologous recombination repair deficiency     genetic heterogeneity    

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Title Author Date Type Operation

G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma

Wenjing Wang, Shigang Ding, Hejun Zhang, Jun Li, Jun Zhan, Hongquan Zhang

Journal Article

Bioinformatic exploration of MTA1-regulated gene networks in colon cancer

Chunxiao Li,Haijuan Wang,Feng Lin,Hui Li,Tao Wen,Haili Qian,Qimin Zhan

Journal Article

Pyogenic liver abscess as initial presentation in locally advanced right colon cancer invading the liver

Kai Qu, Chang Liu, Aasef M A Mansoor, Bo Wang, Jincai Chen, Liang Yu, Yi Lv

Journal Article

Invasive mucinous adenocarcinoma with lepidic-predominant pattern coexisted with tuberculosis: a case

Xinxin Xu, Yinshi Guo, Qiuying Li, Ling Yang, Jianqiang Kang

Journal Article

Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell

SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping

Journal Article

Synchronous rectal adenocarcinoma and anal canal adenocarcinoma

GU Jin, YAO Yunfeng, LI Jiyou, LU Aiping, WANG Hongyi

Journal Article

Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis

Rui ZHU MD, Heng FAN MD, Lin SHEN MD, Jianguo LIU BD, Jia ZHAO MM,

Journal Article

Diversity of the N-Glycome from Microdissected Regions of Colorectal Cancer, Stroma, and Normal Colon

Di Wang, Katarina Madunić , Tao Zhang, Guinevere S.M. Lageveen-Kammeijer, Manfred Wuhrer

Journal Article

Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma

Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen

Journal Article

Hu Qiuhui: Based on AOM / DSS Colon Cancer Model to Explore the Difference of Biological Activity between

胡秋辉(高级职称)

20 Jan 2021

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